Piperonyl butoxide is a very prominent insecticide synergistic agent, in addition to dozens of times to improve the insecticide insecticide effect can also prolong the use of time, increase the broad spectrum of insecticide. Piperonyl butoxide is widely used in agriculture, household health and storage insecticides. It is the only insecticidal synergist approved by the United Nations Health Organization for food health (food production).

It can improve the insecticidal activity of pyrethrin and a variety of pyrethrins, rotenone and carbamate insecticides, and also has synergistic effect on the insecticide of pyrethrin, dichlorvos, chlordane, trichloroinsecticide, atrazine, and can improve the stability of pyrethrin extract.

However, cypermethrin could not increase the knockdown effect on musca domestica. In mosquito-repellent incense, there is no synergistic effect on the permethrin, or even reduce the efficacy.

Used to kill insects, such as grain weevil, that develop during storage of grains such as rice, wheat and beans. It is often combined with the insecticide pyrethrin to form a complex for synergistic effect.

The mortality rate was 46% when pyrethrin was used alone (housefly for example), and 92% when pyrethrin was used in combination with this product (30mg+400mg). The product is usually mixed with 10 times the amount of pyrethrin and prepared into 0.05% ~ 0.2% emulsion or powder.

When pyrethrin was 0.025g in 100ml refined kerosene, the death rate of m. domestica was only 19%, 32% and 50% when pyrethrin was 0.050g and 0.100g respectively. When pyrethrin was 0.025g+0.25g piperonyl butoxide in 100ml refined kerosene, the death rate of  is up to 85%.

The mortality rate of body lice was 78% when pyrethrin and piperonyl are 0.005% and 0.05% respectively. The mortality rate of body lice could reach 100% when containing 0.025% pyrethrin and 0.125% piperonyl, but the mortality rate of body lice was 0 when containing pyrethrin alone.